4-Methylbenzylidene camphor

CAS No. 36861-47-9

4-Methylbenzylidene camphor( 4-MBC | Enzacamene )

Catalog No. M20885 CAS No. 36861-47-9

4-Methylbenzylidene camphor is an ultraviolet light blocker used in cosmetics and sunscreen preparations specifically UV B radiation also has estrogenic activities.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
500MG 49 In Stock
1G 81 In Stock

Biological Information

  • Product Name
    4-Methylbenzylidene camphor
  • Note
    Research use only, not for human use.
  • Brief Description
    4-Methylbenzylidene camphor is an ultraviolet light blocker used in cosmetics and sunscreen preparations specifically UV B radiation also has estrogenic activities.
  • Description
    4-Methylbenzylidene camphor is an ultraviolet light blocker used in cosmetics and sunscreen preparations specifically UV B radiation also has estrogenic activities.
  • In Vitro
    Cell Proliferation AssayCell Line:HTR8/SVneo cells Concentration:0, 5, 10, 20, 50, 100, 200, and 400 μM Incubation Time:48 hResult:Dose-dependently inhibited cell proliferation of HTR8/SVneo cell.Apoptosis Analysis Cell Line:HTR8/SVneo cells Concentration:10, 20, 50 μMIncubation Time:48 hResult:Early and late apoptotic cells was significantly increased at 20 μM and 50 μM. Cell Cycle Analysis Cell Line:HTR8/SVneo cells Concentration: 5, 10, 20, 50 μM Incubation Time:48 h Result:Gradually increased the proportion of cells in the SubG1 phase. Cell Invasion Assay Cell Line:HTR8/SVneo cells Concentration:50 μM Incubation Time:48 hResult:Revealed a significant reduction of 81.5% in invasivenes0.Western Blot Analysis Cell Line:HTR8/SVneo cells Concentration:50 μM Incubation Time:0, 5, 15, 30, 60, 120 min Result:The phosphorylation of AKT and its downstream kinase protein, P70S6K, peaked at 5 and 15 min, respectively, subsequently decreased after 30 min, and then reactivated at 120 min RT-PCR Cell Line:HTR8/SVneo cells Concentration:20, 50 μM Incubation Time:24 h Result:Significantly increased the expression of semaphorin 6 A (SEMA6 A), GPR56, integrin subunit beta 4 (ITGB4), EPHB4, neuropilin 1 (NRP1).
  • In Vivo
    ——
  • Synonyms
    4-MBC | Enzacamene
  • Pathway
    Endocrinology/Hormones
  • Target
    AChR
  • Recptor
    AChE
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    36861-47-9
  • Formula Weight
    254.37
  • Molecular Formula
    C18H22O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:47 mg/mL (184.77 mM)
  • SMILES
    Cc1ccc(C=C2C(=O)C3(C)CCC2C3(C)C)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Stefan D Kirsten M Margret S et al. Estrogen Target Gene Regulation and Coactivator Expression in Rat Uterus after Developmental Exposure to the Ultraviolet Filter 4-Methylbenzylidene Camphor[J]. Endocrinology(5):5.
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